Germline mutation analysis ofhPMS2gene in Chinese families with hereditary nonpolyposis colorectal cancer

Evaluation of MLH1 and MSH2 Gene Mutations in a Subset of Iranian Families with Hereditary Nonpolyposis Colorectal Cancer (HNPCC)

Hereditary nonpolyposis colorectal cancer.

Hereditary nonpolyposis colorectal cancer (HNPCC), or Lynch syndrome, is the most common form of hereditary colorectal cancer (CRC). A well-orchestrated cancer family history is essential for its diagnosis since, unlike its familial adenomatous polyposis (FAP) hereditary cancer counterpart, HNPCC lacks distinguishing clinical stigmata of its cancer genetic risk. Discoveries in the 1990s of germ...

hereditary nonpolyposis colorectal cancer in northeastern iran

background: there are no data on familial aggregation of colorectal cancer (crc) in northeastern iran. the aim of this study was to determine the prevalence of early-onset crc and patients suspected for hereditary non-polyposis colorectal cancer (hnpcc) based on the clinical criteria in this area. materials and methods: documents were collected from two hospitals in mashhad regarding 326 inpati...

Identification of germline mutations in hereditary nonpolyposis colorectal cancer using base excision sequence scanning analysis.

Nonpolyposis Colorectal Cancer Using Base Excision Sequence Scanning Analysis, Angela Brieger, Jörg Trojan, Jochen Raedle, W. Kurt Roth, and Stefan Zeuzem ( Medizinische Klinik II, Klinikum der Johann Wolfgang Goethe-Universität and 2 Blutspendedienst Hessen, D-60590 Frankfurt a.M., Germany; * address correspondence to this author at: Medizinische Klinik II, Zentrum der Inneren Medizin, Kliniku...

Retrospective analysis of patients with hereditary nonpolyposis colorectal cancer (HNPCC)

We performed a one–center cohort retrospective analysis of 1378 non-selected patients operated for colorectal cancer (CRC) in the years 1994 – 2013. For the purpose of this study we divided patients into three subdivisions reflecting their family history of HNPCC–associated cancers among firstand second-degree relatives. On detailed pedigree analysis of the families we identified 59 patients as...